Key Leaders’ Opinion on Immune and Exosome

Posted On 2018-10-12 14:31:35
Key Leaders’ Opinion on Immune and Exosome
Editors: Xinxiang Li, Emre Gorgun, Marco Milone

Publisher: AME Publishing Company; 1st edition (2018)
ISBN-13: 978-988-78920-4-5
Hardcover: 113 pages
Language: English
Available at:

The attributes of EVs discussed in this book provide for an interesting overview of the multiple roles EV subsets assume in several different human diseases. The book consists of a series of short and focused chapters grouped by a common theme and covering EV-mediated contributions to cancer, hematopoiesis, inflammatory conditions, tissue repair, infections or immune therapies. This selected series of short and focused presentations is an easy read. At the same time, it provides a comprehensive appraisal of the recent progress in the EV biology.


Zhijun Han Department of Laboratory Medicine, Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu, China
Theresa L. Whiteside Professor of Pathology, Immunology and Otolaryngology, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Suite 1.32, Pittsburgh, PA 15213, USA
Pietro Invernizzi Associate Professor, Director, Program for Autoimmune Liver Diseases, International Center for Digestive Health, Department of Medicine and Surgery, University of Milan- Bicocca, Via Cadore 48, 20900 Monza (MB), Italy


Mingzhu Gao Department of Laboratory Medicine, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
Mingzhe Ning Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China
Tingwang Jiang Department of Key Laboratory and Microbiology, Institution of Laboratory Medicine of Changshu, Changshu, China


Cheng Chen Medical Technology Institute, Xuzhou Medical University, Xuzhou, China
Xianfen Gao Medical Technology Institute, Xuzhou Medical University, Xuzhou, China
Xiaowei Hu Department of Laboratory Medicine, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
Haohao Liu Department of Laboratory Medicine, The Affiliated Wuxi No.2 People’s Hospital of Nanjing Medical University, Wuxi, China
Runqiu Xia Medical Technology Institute, Xuzhou Medical University, Xuzhou, China
Aiyan Zhang Medical Technology Institute, Xuzhou Medical University, Xuzhou, China
Miguel Abal Translational Medical Oncology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (SERGAS), Trav. Choupana s/n 15706 Santiago de Compostela, Spain
Riccardo Alessandro Biopathology and Biomedical Methodology, Biology and Genetic Section, University of Palermo, Palermo, Italy
Giada Amodio San Raffaele Telethon Institute for Gene Therapy (SR- Tiget), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scienti c Institute, Milan, Italy
Table of Contents
Introduction of Vesicles
1 On the function and heterogeneity of extracellular vesicles
4 Extracellular vesicles isolation and their biomarker potential: are we ready for testing?
8 Extracellular vesicle isolation: present and future
Immune-Related Disease
11 Myeloid-derived suppressor cell, arginase-1, IL-17 and cl-CD95L: an explosive cocktail in lupus?
14 Protection against lupus-like inflammatory disease is in the LAP of non-canonical autophagy
20 Vascular changes and perifascicular muscle fiber damage in dermatomyositis: another question of the chicken or the egg that is on our mind
23 The “gut microbiota” hypothesis in primary sclerosing cholangitis
Extracellular Vesicles & Immune
26 Extracellular vesicles: important players in immune homeostasis
28 Characterizing the contribution of inflammasome-derived exosomes in the activation of the immune response
31 Exosomes, your body’s answer to immune health
34 Tumor exosomal microRNAs thwarting anti-tumor immune responses in nasopharyngeal carcinomas
38 Future directions of extracellular vesicle-associated miRNAs in metastasis
Vesicles & Cancer Immunotherapy
44 Therapeutic targeting of dysregulated cellular communication
50 Is the exosome a potential target for cancer immunotherapy?
52 Cancer exosomes: wanted by many, explored by few, waiting for one
55 Extracellular vesicles: emerging mediators of intercellular communication and tumor angiogenesis
58 Exosomes as delivery vehicles: a commentary on “Amoxicillin haptenates intracellular proteins that can be transported in exosomes to target cells”
62 Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges
Vesicles & Other Immune Diseases
65 Immunosuppressive role of extracellular vesicles: HLA-G, an important player
68 The discovery of HLA-G-bearing extracellular vesicles: new perspectives in HLA-G biology
71 Exosomes may play a crucial role in HIV dendritic cell immunotherapy
74 An immunoregulatory role of dendritic cell-derived exosomes versus HIV-1 infection: take it easy but be warned
82 Donor-derived exosomes: key in lung allograft rejection?
85 Exosomes derived from stimulated monocytes promote endothelial dysfunction and inflammation in vitro
Vesicles & Tissue Repair Function
88 Extracellular vesicles: small bricks for tissue repair/regeneration
93 Nexus between extracellular vesicles, immunomodulation and tissue remodeling: for good or for bad?
99 Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science
Vesicles & Clinical Application
102 Extracellular vesicle-mediated communication in host-parasite interactions: insight from Fasciola hepatica
106 Exosome-like vesicles of helminths: implication of pathogenesis and vaccine development
109 A novel role of exosomes in the vaccination approach
112 Not all extracellular vesicles were created equal: clinical implications

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