Key Leaders’ Opinion on Critical Care Medicine

Posted On 2017-09-06 03:32:55
Key Leaders’ Opinion on Critical Care Medicine
Editors: Zhongheng Zhang, Jordi Rello, Ming Zhong

Publisher: AME Publishing Company; 1st edition (2016)
ISBN-13: 978-9881402899
Hardcover: 185 pages
Language: English
Available at:

The Key Leaders’ Opinion on Critical Care Medicine (AME Medical Review Series 003), with Drs. Zhongheng Zhang (Jinhua municipal central hospital), Dr. Jordi Rello (Vall d’Hebron University Hospital) and Ming Zhong (Zhongshan Hospital) as Editors of the book, focuses on mechanical ventilation, sepsis and infection, cardiac arrest and cardiopulmonary resuscitation, extracorporeal support, delirium and sedation, outcome of the critically ill patient, and methodology of study design.

Clinical management, education and training as well as research must be considered for optimizing the overall treatment of critically ill patients. These topics are of particular relevance not only in providing updated information but also to support clinicians in developing educational and training strategies as well as better interpretation and design of experimental and clinical studies.

Honorary Editors

Paolo Pelosi IRCCS AOU San Martino-IST, Italy
Claude Guérin Institut Mondor de Recherche Biomédicale, France


Zhongheng Zhang Jinhua municipal central hospital, China
Jordi Rello Vall d'Hebron University Hospital, Spain
Ming Zhong Zhongshan Hospital, China


Scott Aberegg Jordan Valley Medical Center, West Jordan, UT, USA
Penny Andrews Department of Trauma Critical Care Medicine, R Adams Cowley Shock Trauma Center, Baltimore, MD, USA
Elisabete Aramendi Communications Engineering Department, University of the Basque Country UPV/EHU, Alameda Urquijo S/N 48013 Bilbao, Spain
Mabrouk Bahloul Service de Réanimation Médicale, CHU Habib Bourguiba, Sfax, Tunisie
Lorenzo Ball IRCCS AOU San Martino-IST, Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 116131 Genoa, Italy
Carmen Sílvia Valente Barbas Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil; Pulmonary Division, Heart Institute and Hospital das Clinicas of University of São Paulo Medical School, São Paulo, Brazil
Sean S. Barnes Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Charlotte R. Bloomberg Children’s Center, Baltimore, MD 21287, USA
Angela Bates University of Alberta, Stollery Children’s Hospital, Edmonton, Alberta, Canada
Sarah J. Beesley Pulmonary and Critical Care, University of Utah School of Medicine, Salt Lake City, UT, USA
Thomas Bein Department of Anesthesia, Operative Intensive Care, University Hospital Regensburg, D-93042 Regensburg, Germany
Abhishek Biswas Division of Pulmonary and Critical Care Medicine, University of Florida, Gainesville 32610, USA
Willem Boer Department of Anesthesiology, Critical Care, Emergency Medicine and Pain Therapy, Ziekenhuis Oost-Limburg, 3600 Genk, Belgium
Mounir Bouaziz Service de Réanimation Médicale, CHU Habib Bourguiba, Sfax, Tunisie
Adrián Camacho-Ortiz Hospital Epidemiology, Hospital Universitario Dr. José Eleuterio González, Monterrey, NL, México
Table of Content
Mechanical Ventilation
1 Supporting respiratory function in the immunocompromised critically ill patient: new perspectives for an old paradigm
4 New puzzles for the use of non-invasive ventilation for immunosuppressed patients
8 Non-invasive ventilation in immunocompromised patients with acute hypoxemic respiratory failure
17 Conservative versus liberal oxygenation targets for mechanically ventilated patients—a pilot multicenter randomized controlled trial
21 Permissive hypoxemia/conservative oxygenation strategy: Dr. Jekyll or Mr. Hyde?
24 From Berlin to Kigali: the sobering journey of acute respiratory distress syndrome
27 The Kigali modi cation of the berlin de nition: a new epidemiological tool for ARDS?
30 Acetazolamide use in severe COPD exacerbations requiring invasive mechanical ventilation: impact on duration of mechanical ventilation
33 Intraoperative mechanical ventilation in patients with non-injured lungs: time to talk about tailored protective ventilation?
36 One more brick in the wall of protective ventilation in surgical patients
40 “Open the lung and keep it open”: a homogeneously ventilated lung is a ‘healthy lung’
43 How to improve assessment of balance in baseline characteristics of clinical trial participants—example from PROSEVA trial data?
49 Quanti cation of lung recruitment by respiratory mechanics and CT imaging: what are the clinical implications?
Sepsis and Infection
53 Fever: suppress or let it ride?
57 Acetaminophen in critically ill patients, a therapy in search for big data analytics
59 Acetaminophen for febrile patients with suspected infection: potential bene t and further directions
63 Is there a role for continuous infusion of β-lactam antibiotics in severe sepsis?
66 Balanced control of both hyper and hypo-in ammatory phases as a new treatment paradigm in sepsis
71 Septic shock in the era of precision medicine
73 Sepsis without SIRS is still sepsis
75 Why we need a new de nition of sepsis
79 Forget skin scrubbing and other antiseptics: prevent catheter related infections using chlorhexidine plus alcohol
82 A multimodality approach to prevent catheter-related bloodstream infections: the role of chlorhexidine- alcohol as a skin antiseptic before intravascular catheter insertion
85 What is new for the prevention of catheter-related bloodstream infections?
90 Venous-to-arterial carbon dioxide differences and the microcirculation in sepsis
93 Venous-to-arterial CO2 differences and the quest for bedside point-of-care monitoring to assess the microcirculation during shock
97 Choice of crystalloids in sepsis: a conundrum waiting to be solved
101 Preventing the development of acute cor pulmonale in patients with acute respiratory distress syndrome: the rst step
106 Editorial on low-dose acetylsalicylic acid treatment and impact on short-term mortality in staphylococcus aureus bloodstream infection: a propensity score-matched cohort study
Cardiac Arrest and CPR
109 Continuous or interrupted chest compressions for EMS-performed cardiopulmonary resuscitation
112 To interrupt, or not to interrupt chest compressions for ventilation: that is the question!
115 What can a simple measure of heart rate during temperature management tell us on the physiology and prognosis of comatose cardiac arrest patients?
Outcome for the Critically ill
119 A modi ed Sequential Organ Failure Assessment score using the Richmond Agitation-Sedation Scale in critically ill patients
122 Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients
129 Utility of the Richmond Agitation-Sedation Scale in evaluation of acute neurologic dysfunction in the intensive care unit
132 Serum lactate level as a useful predictor of clinical outcome after surgery: an unful lled potential?
135 Lactate: the “Black Peter” in high-risk gastrointestinal surgery patients
Delirium and Sedation
138 Can the critical-care pain observation tool (CPOT) be used to assess pain in delirious ICU patients?
141 The impact of sedation protocols on outcomes in critical illness
144 The best sedation drug—a quest for the holy grail?
146 Sedative choice and ventilator-associated patient outcomes: don’t sleep on delirium
Extracorporeal Support
149 The delicate balance between pro-(risk of thrombosis) and anti-(risk of bleeding) coagulation during extracorporeal membrane oxygenation
153 Hemostatic changes during extracorporeal membrane oxygenation: a commentary
Methodology of Study Design
156 Challenging orthodoxy in critical care trial design: physiological responsiveness

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