Thymic Malignancy

Posted On 2018-02-07 06:53:44
Thymic Malignancy
Editors:Wentao Fang, Joel Dunning, Robert J. Korst

Publisher: AME Publishing Company; 1st edition (2017)
ISBN-13: 978-9887784029
Hardcover: 244 pages
Language: English
Available at:

Thymic Epithelial Tumors (TETs) are rare neoplastic diseases, but the most common anterior mediastinal tumors in the adulthood. TETs are classified according to the World Health Organization (WHO) histopathological classification, which distinguishes thymomas from thymic carcinomas (tumors cathegory which also includes thymic neuroendocrine ones). Their rarity, along with the lack of randomized clinical trials (RCTs) make TETs’ global management still questioned, and only few clinical recommendations currently exist.

This book illustrates the remarkable results in the study of TET that have been accomplished through collaborative projects at regional and global level. Many of these projects were only possible thanks to established retrospective and prospective regional and international databases. These concerted efforts built a solid foundation for future projects such as the molecular study of TET and studies towards standardized and personal treatment of patients with these tumors amongst other projects.

Honorary Editors

Pier Luigi FilossoThoracic Surgery, University of Torino, Italy
Anja C. RodenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA


Wentao FangDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China
Joel DunningDepartment of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, UK
Robert J. KorstDepartment of Thoracic Surgery, Icahn School of Medicine, Mount Sinai Health System, New York, NY, USA; Valley/ Mount Sinai Comprehensive Cancer Care, Paramus, NJ, USA

Associate Editors

Jianhua FuDepartment of Thoracic Surgery, Guangdong Esophageal Cancer Institute, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China
Zhentao YuDepartment of Esophageal Cancer, Tianjin Cancer Hospital, Tianjin 300060, China; 17Department of Thoracic Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China
Yin LiDepartment of Thoracic Surgery, Af liated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China
Keneng ChenDepartment of Thoracic Surgery, Beijing Cancer Hospital, Beijing 100142, China
Xiaolong FuDepartment of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China
Table of Contents
General Concepts and Strategies in the Management of Thymic Malignancies
1 Management of thymic tumors—consensus based on the Chinese Alliance for Research in Thymomas Multi-institutional retrospective studies
6 The impact of ChART on the science of thymic malignancies
7 Management of thymic tumors: a European perspective
17 Prof. Frank Detterbeck: more attention should be paid to subgroup in the study of rare disease
19 Prof. Robert Korst: PORT in completely resected thymoma—more observation is needed
21 Prognostic strati cation of thymic epithelial tumors based on both Masaoka-Koga stage and WHO classi cation systems
31 CT staging and preoperative assessment of resectability for thymic epithelial tumors
41 Only when all contribute their firewood can they build up a big fire
44 Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database
55 The International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems for thymic epithelial tumors and large-scale retrospective data
58 The enlightenments from ITMIG Consensus on WHO histological classi cation of thymoma and thymic carcinoma: re ned de nitions, histological criteria, and reporting
64 Clinicopathological analysis of 241 thymic epithelial tumors—experience in the Shanghai Chest Hospital from 1997–2004
73 Thymic epithelial tumors in a worldwide perspective: lessons from observational studies
78 Pretreatment biopsy for histological diagnosis and induction therapy in thymic tumors
87 Pretreatment biopsy for thymic epithelial tumors—does histology subtype matter for treatment strategy?
93 Preoperative induction therapy for locally advanced thymic tumors: a retrospective analysis using the ChART database
101 Multimodality therapy for locally-advanced thymic epithelial tumors: where are we now?
104 The role of postoperative radiotherapy for stage I/II/III thymic tumor—results of the ChART retrospective database
113 The application of postoperative chemotherapy in thymic tumors and its prognostic effect
122 How large databases may impact clinical practices for rare tumors—postoperative chemotherapy in thymic malignancies
124 Outcome of nonsurgical treatment for locally advanced thymic tumors
130 Non-surgical treatment of locally advanced thymic epithelial tumors—a need for multicenter trials
134 Postoperative survival for patients with thymoma complicating myasthenia gravis—preliminary retrospective results of the ChART database
141 Editorial on “Postoperative survival for patients with thymoma complicating myasthenia gravis— preliminary retrospective results of the ChART database”
Surgical Therapies for Thymic Malignancies
143 Thymectomy versus tumor resection for early-stage thymic malignancies: a Chinese Alliance for Research in Thymomas retrospective database analysis
150 Thymomectomy in early stage thymomas—case closed?
153 Standardized de nitions and policies of minimally invasive thymoma resection
158 Video-assisted thoracoscopic surgery versus open thymectomy for thymoma: a systematic review
172 Minimally invasive versus open thymectomy: a systematic review of surgical techniques, patient demographics, and perioperative outcomes
181 Endoscopic thymectomy: a neurologist’s perspective
188 Perioperative outcomes and long-term survival in clinically early-stage thymic malignancies: video- assisted thoracoscopic thymectomy versus open approaches
195 Early stage thymoma: is VATS the new standard of care?
198 Minimally invasive thymectomy: the Mayo Clinic experience
206 Multi-institutional European experience of robotic thymectomy for thymoma
214 Subxiphoid uniportal thoracoscopic extended thymectomy
217 Subxiphoid and subcostal arch thoracoscopic extended thymectomy: a safe and feasible minimally invasive procedure for selective stage III thymomas
224 Thymectomy via a subxiphoid approach: single-port and robot-assisted
231 Left- and right-sided video-assisted thoracoscopic thymectomy exhibit similar effects on myasthenia gravis
240 Video assisted thoracic surgery (VATS) for recurrent thymoma

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