Sepsis and Infection
53 Fever: suppress or let it ride?
57 Acetaminophen in critically ill patients, a therapy in search for big data analytics
59 Acetaminophen for febrile patients with suspected infection: potential bene t and further directions
63 Is there a role for continuous infusion of β-lactam antibiotics in severe sepsis?
66 Balanced control of both hyper and hypo-in ammatory phases as a new treatment paradigm in sepsis
71 Septic shock in the era of precision medicine
73 Sepsis without SIRS is still sepsis
75 Why we need a new de nition of sepsis
79 Forget skin scrubbing and other antiseptics: prevent catheter related infections using chlorhexidine plus alcohol
82 A multimodality approach to prevent catheter-related bloodstream infections: the role of chlorhexidine- alcohol as a skin antiseptic before intravascular catheter insertion
85 What is new for the prevention of catheter-related bloodstream infections?
90 Venous-to-arterial carbon dioxide differences and the microcirculation in sepsis
93 Venous-to-arterial CO2 differences and the quest for bedside point-of-care monitoring to assess the microcirculation during shock
97 Choice of crystalloids in sepsis: a conundrum waiting to be solved
101 Preventing the development of acute cor pulmonale in patients with acute respiratory distress syndrome: the rst step
106 Editorial on low-dose acetylsalicylic acid treatment and impact on short-term mortality in staphylococcus aureus bloodstream infection: a propensity score-matched cohort study
Cardiac Arrest and CPR
109 Continuous or interrupted chest compressions for EMS-performed cardiopulmonary resuscitation
112 To interrupt, or not to interrupt chest compressions for ventilation: that is the question!
115 What can a simple measure of heart rate during temperature management tell us on the physiology and prognosis of comatose cardiac arrest patients?
Outcome for the Critically ill
119 A modi ed Sequential Organ Failure Assessment score using the Richmond Agitation-Sedation Scale in critically ill patients
122 Serum creatinine level, a surrogate of muscle mass, predicts mortality in critically ill patients
129 Utility of the Richmond Agitation-Sedation Scale in evaluation of acute neurologic dysfunction in the intensive care unit
132 Serum lactate level as a useful predictor of clinical outcome after surgery: an unful lled potential?
135 Lactate: the “Black Peter” in high-risk gastrointestinal surgery patients
Delirium and Sedation
138 Can the critical-care pain observation tool (CPOT) be used to assess pain in delirious ICU patients?
141 The impact of sedation protocols on outcomes in critical illness
144 The best sedation drug—a quest for the holy grail?
146 Sedative choice and ventilator-associated patient outcomes: don’t sleep on delirium
149 The delicate balance between pro-(risk of thrombosis) and anti-(risk of bleeding) coagulation during extracorporeal membrane oxygenation
153 Hemostatic changes during extracorporeal membrane oxygenation: a commentary
Methodology of Study Design
156 Challenging orthodoxy in critical care trial design: physiological responsiveness